Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 19/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 19/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 17/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.69 |
| ▸ | TSHR | P16473 | 15/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.69 |
| ▸ | LMNA | P02545 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | GLA | P06280 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 12/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | APLNR | P35414 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861102 | 0.90 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL5752435 | 0.90 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL27661951 | 0.88 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL15465606 | 0.85 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL3451889 | 0.83 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4823978 | 0.83 | CYP1A2 (0.70) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL16368537 | 0.82 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL20238115 | 0.82 | TSHR (0.54) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL31678589 | 0.81 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL31678617 | 0.81 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820704-B2 | Substituted heteroaryl derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1753735-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Transtech Pharma, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-11-24 | — | — | US | disclosed |
| WO-2005103022-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | TRANSTECH PHARMA, INC. (US) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | MC5R, MC3R, MC4R | CYP1A2 261/4885CYP3A4 929/4885CYP2C19 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.