Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.56 |
| ▸ | TSHR | P16473 | 13/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 10/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861102 | 1.00 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL3452299 | 0.90 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4823978 | 0.83 | CYP1A2 (0.70) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL27661951 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL13504222 | 0.80 | CLK4 (0.68) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL14486766 | 0.80 | CYP3A4 (0.51) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL28114877 | 0.78 | CLK4 (0.61) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL4820325 | 0.75 | GAA (0.62) | LMNAALDH1A1USP2MEN1KMT2A | |
| SCHEMBL15465606 | 0.74 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL3451889 | 0.73 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654238-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005009978-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |