Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nortriptyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 1.00 |
| ▸ | HRH1 | P35367 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 6/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | DRD2 | P14416 | 5/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 5/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 5/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 5/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | HTR2C | P28335 | 5/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 5/20 | 1.00 |
| ▸ | DRD3 | P35462 | 5/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nortriptyline SCHEMBL29362430 | 1.00 | SLC6A2 (1.00) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL1286980 | 1.00 | SLC6A2 (1.00) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL41329 | 0.98 | CYP3A4 (1.00) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL29751879 | 0.98 | CYP3A4 (1.00) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL7158809 | 0.98 | SLC6A2 (0.97) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL7092935 | 0.97 | LMNA (0.94) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Nortriptyline SCHEMBL2244623 | 0.97 | SLC6A2 (0.94) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| Amitriptyline SCHEMBL3897883 | 0.90 | SLC6A2 (0.81) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| SCHEMBL21859431 | 0.89 | LMNA (0.78) | SLC6A2HRH1LMNACYP3A4CYP1A2 | |
| SCHEMBL22147029 | 0.89 | LMNA (0.78) | SLC6A2HRH1LMNACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33706 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| CN-122035985-A | Magnetic eutectic solvent, preparation method and application thereof, pretreatment method of antidepressant-containing wastewater and quantitative detection method | 山西医科大学 | 2026-05-15 | — | — | CN | claimed |
| US-20260131089-A1 | DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY | APTARGROUP, INC. (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130868-A1 | METHODS FOR TREATING NEURODEVELOPMENTAL DISORDERS VIA ADMINISTRATION OF ORGANIC TRICYCLIC COMPOUNDS | SYNGAP RES FUND (US) | 2026-05-14 | — | — | US | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| CN-122011028-A | Method for efficiently preparing various substituted chiral phosphoramides | 上海交通大学 | 2026-05-12 | — | — | CN | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-20260115192-A1 | PHARMACEUTICAL COMPOSITIONS | SHENZHEN PHARMACIN CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| EP-0093373-A1 | Method and composition for treating and preventing irritation of the mucous membranes of the nose | Bernstein, Joel E. (US) | 1983-11-09 | — | — | EP | claimed |
| US-4401764-A | Immunoassays employing labeled reagent and a conjugate having two binding sites | TECHNICON INSTRUMENTS CORPORATION (US) | 1983-08-30 | — | — | US | claimed |
| US-4375466-A | Method of determining and treating affective illness | LEUSCHNER JANET | 1983-03-01 | — | — | US | claimed |
| US-4370324-A | Method and composition for treating and preventing irritation of the eyes | BERNSTEIN JOEL E (US) | 1983-01-25 | — | — | US | claimed |
| EP-0048023-A2 | Composition for treating and preventing irritation of the eyes | Bernstein, Joel E., M.D. (US) | 1982-03-24 | — | — | EP | claimed |
| EP-0044441-A1 | Monoclonal antibodies to drugs, methods for their production and somatic cell hybridomas secreting them | MILES LABORATORIES, INC. (US) | 1982-01-27 | — | — | EP | claimed |
| EP-0034050-A2 | Immunoassay of antigens | TECHNICON INSTRUMENTS CORPORATION (a New York corporation) (US) | 1981-08-19 | — | — | EP | claimed |
| US-4279992-A | Specific binding assay employing an enzyme-cleavable substrate as label | MILES LABORATORIES, INC. (US) | 1981-07-21 | — | — | US | claimed |
| US-4207307-A | Simultaneous immunoassay of multiple antigens and assay for cocaine metabolites | RESEARCH CORPORATION (US) | 1980-06-10 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |