Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.62 |
| ▸ | C1R | P00736 | 2/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3452649 | 0.79 | ELANE (0.68) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3453029 | 0.79 | NPC1 (0.71) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3453309 | 0.79 | ELANE (0.68) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3452604 | 0.77 | ELANE (1.00) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3453106 | 0.76 | ELANE (0.65) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3453469 | 0.76 | ELANE (0.68) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL11818974 | 0.76 | NPC1 (0.53) | C1RKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL13224725 | 0.75 | ELANE (0.63) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL13224723 | 0.75 | ELANE (0.63) | ELANEC1RKDM4ENPC1RAB9A | |
| SCHEMBL3453528 | 0.75 | ELANE (0.63) | ELANEC1RKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144395-B1 | 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY | ALIZYME THERAPEUTICS LTD (GB) | 2005-04-20 | — | — | EP | claimed |
| US-6656934-B2 | Enzyme inhibitor | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-12-02 | — | — | US | claimed |
| US-20030191123-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2003-10-09 | — | — | US | claimed |
| US-20030013707-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2003-01-16 | — | — | US | claimed |
| WO-2000040569-A9 | 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY | ALIZYME THERAPEUTICS LTD (GB) | 2002-02-28 | — | — | WO | claimed |
| US-7776853-B2 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| US-7776853-B2 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| US-7776853-B2 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| US-6656934-B2 | Enzyme inhibitor | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191123-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | CYP4X1, CYP2B6, BBOX1 | ELANE 730/4885C1R 3778/4885ABCG2 493/4885 |
| US-20030013707-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | CYP4X1, CYP2B6, BBOX1 | ELANE 730/4885C1R 3778/4885ABCG2 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.