Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10075587 | 0.77 | ALDH1A1 (0.74) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL13824739 | 0.77 | CYP1A2 (1.00) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL14760393 | 0.77 | ALDH1A1 (0.74) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| Dichlobenil SCHEMBL1701380 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| Dichlobenil SCHEMBL55606 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL9289883 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL21486448 | 0.74 | KDM4E (1.00) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL2826949 | 0.74 | CYP1A2 (0.57) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| Dichlobenil SCHEMBL28232070 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 | |
| Dichlobenil SCHEMBL10737856 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106674226-B | Antifungal compounds substituted with heterocyclic derivatives | 詹森药业有限公司 | 2020-05-26 | — | — | CN | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9975899-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-22 | — | — | US | disclosed |
| US-9637490-B2 | Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20170073348-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-16 | — | — | US | disclosed |
| US-20170073348-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-16 | — | — | US | disclosed |
| US-20170073348-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-16 | — | — | US | disclosed |
| US-9493468-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-15 | — | — | US | disclosed |
| US-9493468-B2 | Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-15 | — | — | US | disclosed |
| WO-2012150305-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO- DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012084804-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011154298-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-15 | — | — | WO | disclosed |
| US-7820650-B2 | Antifungal 4-substituted 5,6-dihydro-4H-pyrrolo [1,2-a][1,4]benzodiazepines | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-26 | — | — | US | disclosed |
| EP-1392691-B1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A] [1,4] BENZODIAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-20 | — | — | EP | disclosed |
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GILKERSON TERENCE | 2007-10-04 | — | — | US | disclosed |
| US-7202240-B2 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-30 | — | — | US | disclosed |
| EP-1392691-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4 u H /u -PYRROLO 1,2-A] 1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002034752-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232593-A1 | ANTIFUNGAL 4-SUBSTITUTED 5,6-DIHYDRO-4H-PYRROLO [1,2-a][1,4]BENZODIAZEPINES | GABBR1, HRH4, CYP8B1 | ALDH1A1 903/4885MAPT 3016/4885CYP1A2 23/4885 |
| US-20040266756-A1 | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] benzodiazepines | CYP1B1, CBR1, CYP2E1 | ALDH1A1 459/4885MAPT 2627/4885CYP1A2 16/4885 |
| US-20170073348-A1 | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES | GABBR1, HRH4, CYP1B1 | ALDH1A1 410/4885MAPT 3640/4885CYP1A2 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.