Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21924972 | 1.00 | DPP4 (0.50) | DPP4KCNH2SLC7A5DPP7DPP8 | |
| SCHEMBL28055243 | 0.83 | DPP4 (0.49) | DPP4KCNH2SLC7A5DPP7DPP8 | |
| SCHEMBL27899116 | 0.83 | DPP4 (0.49) | DPP4KCNH2SLC7A5DPP7DPP8 | |
| SCHEMBL4002665 | 0.83 | CTSS (0.48) | DPP4SLC7A5 | |
| SCHEMBL11221173 | 0.83 | DPP4 (0.49) | DPP4KCNH2SLC7A5DPP7DPP8 | |
| SCHEMBL1519636 | 0.82 | SLC7A5 (0.43) | DPP4SLC7A5DPP7DPP8CYP2D6 | |
| SCHEMBL28304222 | 0.81 | DPP4 (0.51) | DPP4KCNH2DPP7DPP8DPP9 | |
| SCHEMBL1519830 | 0.77 | CTSS (0.46) | SLC7A5 | |
| SCHEMBL2897783 | 0.75 | IDO1 (0.44) | CYP3A4 | |
| SCHEMBL1521462 | 0.75 | IDO1 (0.44) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107286164-B | Application of compound in preparation of sitagliptin and method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-116554060-B | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-116554060-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-107286164-B | Application of compound in preparation of sitagliptin and method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2021-08-03 | — | — | CN | disclosed |
| CN-107286164-A | Purposes of the compound in sitagliptin is prepared and the method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2017-10-24 | — | — | CN | disclosed |
| US-7820666-B2 | Tetrahydrotriazolopyrazine derivatives and uses thereof | CONCERT PHARMACEUTICALS, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20080280913-A1 | TETRAHYDROTRIAZOLOPYRAZINE DERIVATIVES AND USES THEREOF | CONCERT PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| US-20070197522-A1 | Dpp-iv inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197522-A1 | Dpp-iv inhibitors | DPP7, DPP4, DPP3 | DPP4 2/4885KCNH2 880/4885SLC7A5 776/4885 |
| US-20080280913-A1 | TETRAHYDROTRIAZOLOPYRAZINE DERIVATIVES AND USES THEREOF | DPP4, DPP3, DPP7 | DPP4 1/4885KCNH2 1903/4885SLC7A5 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.