Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451514 | 1.00 | GSK3B (0.54) | GSK3BPARP10PTPN1KMT2AGRIN1 | |
| SCHEMBL3451516 | 1.00 | GSK3B (0.54) | GSK3BPARP10PTPN1KMT2AGRIN1 | |
| SCHEMBL17873447 | 0.92 | GSK3B (0.58) | GSK3BPARP10PTPN1EPHX2MAP4K4 | |
| SCHEMBL3454901 | 0.81 | SMN1; SMN2 (0.54) | PARP10EPHX2MAP4K4HRH3ALDH1A1 | |
| SCHEMBL3453265 | 0.81 | SMN1; SMN2 (0.54) | PARP10EPHX2MAP4K4HRH3ALDH1A1 | |
| SCHEMBL13699366 | 0.81 | ALDH1A1 (0.60) | PARP10EPHX2ALDH1A1LMNACASP3 | |
| SCHEMBL9640923 | 0.78 | HRH1 (0.43) | PARP10PTPN1EPHX2HRH3 | |
| SCHEMBL17190314 | 0.77 | ALDH1A1 (0.55) | PARP10EPHX2MAP4K4ALDH1A1LMNA | |
| SCHEMBL20326426 | 0.77 | PARP10 (0.44) | PARP10PTPN1KMT2AEPHX2MAP4K4 | |
| SCHEMBL22563077 | 0.75 | EPHX2 (0.63) | PARP10EPHX2ALDH1A1LMNACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820704-B2 | Substituted heteroaryl derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1753735-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Transtech Pharma, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-11-24 | — | — | US | disclosed |
| WO-2005103022-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | TRANSTECH PHARMA, INC. (US) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | MC5R, MC3R, MC4R | GSK3B 1238/4885PARP10 2619/4885PTPN1 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.