Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.78 |
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2412199 | 0.92 | HDAC1 (0.75) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL13202035 | 0.91 | HDAC2 (0.65) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL6571020 | 0.89 | HDAC2 (1.00) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL17549783 | 0.88 | HDAC2 (1.00) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL29349778 | 0.88 | HDAC2 (1.00) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL3037525 | 0.87 | HDAC6 (0.60) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL3034370 | 0.86 | NPC1 (0.65) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL3028189 | 0.86 | NPC1 (0.63) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL3034071 | 0.86 | NPC1 (0.61) | HDAC2HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL3032709 | 0.85 | HDAC1 (0.64) | HDAC2HDAC6HDAC8HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |