Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 10/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454460 | 0.91 | HDAC2 (0.80) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL11641490 | 0.90 | NR1H4 (0.59) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL4153362 | 0.88 | NPC1 (0.69) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL2412199 | 0.88 | HDAC1 (0.75) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL5969148 | 0.84 | ESRRG (0.60) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL14894197 | 0.84 | NR1H4 (0.85) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6410116 | 0.84 | SMN1; SMN2 (0.72) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18759257 | 0.83 | HDAC3 (0.53) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL17946070 | 0.83 | HDAC3 (0.62) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL9039897 | 0.82 | HDAC3 (0.59) | HDAC2HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767777-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-7767777-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| EP-1924590-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2009-10-14 | — | — | EP | disclosed |
| US-20090048415-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2009-02-19 | — | — | US | disclosed |
| US-20090048415-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2009-02-19 | — | — | US | disclosed |
| WO-2007031185-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048415-A1 | METAL COMPLEXES | SOD1, IK, AP1M1 | HDAC2 2802/4885HDAC8 4564/4885HDAC6 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.