Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.48 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7056467 | 1.00 | TSHR (0.54) | TSHRHTTPOLBAPEX1TDP1 | |
| Bromide SCHEMBL31748176 | 1.00 | TSHR (0.54) | TSHRHTTPOLBAPEX1TDP1 | |
| Bromide SCHEMBL31748172 | 1.00 | TSHR (0.54) | TSHRHTTPOLBAPEX1TDP1 | |
| Bromide SCHEMBL7058976 | 1.00 | TSHR (0.54) | TSHRHTTPOLBAPEX1TDP1 | |
| SCHEMBL6397609 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 | |
| Hydrochloric Acid SCHEMBL7055391 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 | |
| Hydrochloric Acid SCHEMBL9132796 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 | |
| Hydrochloric Acid SCHEMBL1032458 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 | |
| SCHEMBL6860941 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 | |
| Hydrochloric Acid SCHEMBL346360 | 0.98 | TSHR (0.56) | TSHRHTTPOLBAPEX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 465 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025122636-A1 | METHOD FOR THE SYNTHESIS OF ACRYLATE DERIVATIVES | Orthobond Corporation (US) | 2025-06-12 | — | — | WO | claimed |
| US-12023405-B2 | Antimicrobial polymer for use in ophthalmic implants | KERAMED INC (US) | 2024-07-02 | — | — | US | claimed |
| US-20240197965-A1 | FOAM BIOMATERIAL AND SYSTEMS, METHODS, AND DEVICES FOR MAKING AND USING SAME | UNIV CONNECTICUT (US) | 2024-06-20 | — | — | US | claimed |
| US-20240082114-A1 | DENTAL CEMENT | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-14 | — | — | US | claimed |
| EP-4268793-A1 | DENTAL CEMENT | Kuraray Noritake Dental Inc. (JP) | 2023-11-01 | — | — | EP | claimed |
| EP-3850018-B1 | ANTIMICROBIAL CONTACT LENSES | KERAMED INC (US) | 2023-08-23 | — | — | EP | claimed |
| EP-3509593-B1 | ANTIMICROBIAL POLYMER FOR USE IN OPHTHALMIC IMPLANTS | KERAMED INC (US) | 2022-11-09 | — | — | EP | claimed |
| WO-2022217058-A1 | FOAM BIOMATERIAL AND SYSTEMS, METHODS, AND DEVICES FOR MAKING AND USING SAME | TAMAYOL ALI (US) | 2022-10-13 | — | — | WO | claimed |
| WO-2022182713-A1 | METHODS OF PHOTOGRAFTING TO SURFACE METAL OXIDES | Orthobond Corporation (US) | 2022-09-01 | — | — | WO | claimed |
| US-20220266296-A1 | Methods of Photografting to Surface Metal Oxides | Orthobond Corporation | 2022-08-25 | — | — | US | claimed |
| US-9872938-B2 | Methods, compositions and techniques for polydimethylsiloxane surface modifications | ORTHOBOND, INC. (US) | 2018-01-23 | — | — | US | claimed |
| WO-2016191378-A1 | METHODS, COMPOSITIONS AND TECHNIQUES FOR POLYDIMETHYLSILOXANE SURFACE MODIFICATIONS | ORTHOBOND, INC. (US) | 2016-12-01 | — | — | WO | claimed |
| US-20160340461-A1 | METHODS, COMPOSITIONS AND TECHNIQUES FOR POLYDIMETHYLSILOXANE SURFACE MODIFICATIONS | ORTHOBOND, INC. | 2016-11-24 | — | — | US | claimed |
| US-8889196-B2 | Dental composites comprising nanoparticles of amorphous calcium phosphate | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-11-18 | — | — | US | claimed |
| US-20140050674-A1 | Method for Improving Penetration or Long Term Adhesion of Compositions to Dental Tissues and Compositions Usable in Said Method | UNIVERSITY OF OULU (FI) | 2014-02-20 | — | — | US | claimed |
| EP-2588140-A2 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | University of Maryland, Baltimore (US) | 2013-05-08 | — | — | EP | claimed |
| US-20130108708-A1 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-02 | — | — | US | claimed |
| WO-2012146832-A2 | A METHOD FOR IMPROVING PENETRATION OR LONG TERM ADHESION OF COMPOSITIONS TO DENTAL TISSUES AND COMPOSITIONS USABLE IN SAID METHOD | OULUN YLIOPISTO (FI) | 2012-11-01 | — | — | WO | claimed |
| WO-2012003290-A2 | DENTAL COMPOSITES COMPRISING NANOPARTICLES OF AMORPHOUS CALCIUM PHOSPHATE | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2012-01-05 | — | — | WO | claimed |
| WO-2003105785-A1 | ANTIMICROBIAL PREPREG, COMPOSITE AND THEIR USE | STICK TECH OY (FI) | 2003-12-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240082114-A1 | DENTAL CEMENT | KATNAL2, KLHDC2, KCNJ1 | ACHE 3173/4885CHRM2 3072/4885CHRM4 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.