Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7055391 | 1.00 | TSHR (0.56) | TSHRPOLBAPEX1HTTTDP1 | |
| Hydrochloric Acid SCHEMBL1032458 | 1.00 | TSHR (0.56) | TSHRPOLBAPEX1HTTTDP1 | |
| SCHEMBL6397609 | 1.00 | TSHR (0.56) | TSHRPOLBAPEX1HTTTDP1 | |
| SCHEMBL6860941 | 1.00 | TSHR (0.56) | TSHRPOLBAPEX1HTTTDP1 | |
| Hydrochloric Acid SCHEMBL9132796 | 1.00 | TSHR (0.56) | TSHRPOLBAPEX1HTTTDP1 | |
| Bromide SCHEMBL7058976 | 0.98 | TSHR (0.54) | TSHRPOLBAPEX1HTTTDP1 | |
| Bromide SCHEMBL7056467 | 0.98 | TSHR (0.54) | TSHRPOLBAPEX1HTTTDP1 | |
| Bromide SCHEMBL31748172 | 0.98 | TSHR (0.54) | TSHRPOLBAPEX1HTTTDP1 | |
| Bromide SCHEMBL345541 | 0.98 | TSHR (0.54) | TSHRPOLBAPEX1HTTTDP1 | |
| Bromide SCHEMBL31748176 | 0.98 | TSHR (0.54) | TSHRPOLBAPEX1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | KURARAY NORITAKE DENTAL INC. (JP) | 2024-05-23 | — | — | US | disclosed |
| EP-4364718-A1 | DENTAL CURABLE COMPOSITION | Kuraray Noritake Dental Inc. (JP) | 2024-05-08 | — | — | EP | disclosed |
| US-20240139078-A1 | DENTAL FILLING KIT | KURARAY NORITAKE DENTAL INC. (JP) | 2024-05-02 | — | — | US | disclosed |
| EP-4360609-A1 | DENTAL ADHESIVE KIT | Kuraray Noritake Dental Inc. (JP) | 2024-05-01 | — | — | EP | disclosed |
| US-20240091107-A1 | DENTAL COMPOSITION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-21 | — | — | US | disclosed |
| WO-2024053223-A1 | CARIOUS TOOTH STRUCTURE RECOVERY AGENT, AND DENTAL ADHESIVE KIT | クラレノリタケデンタル株式会社 | 2024-03-14 | — | — | WO | disclosed |
| US-20240074946-A1 | DENTAL COMPOSITION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-07 | — | — | US | disclosed |
| US-20240074945-A1 | CURABLE COMPOSITION FOR DENTAL RESTORATION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-07 | — | — | US | disclosed |
| EP-4324450-A1 | DENTAL FILLING KIT | Kuraray Noritake Dental Inc. (JP) | 2024-02-21 | — | — | EP | disclosed |
| EP-3936109-B1 | SOLVENT-FREE ADHESIVE COMPOSITION FOR DENTAL USE | KURARAY NORITAKE DENTAL INC (JP) | 2024-02-14 | — | — | EP | disclosed |
| US-20030060533-A1 | A metal oxide and a water-soluble metal salt each forming an independent phase; high water resistance and high acid resistance, and high releasing abilities of ions such as fluorine ions | KURARAY NORITAKE DENTAL INC. (JP) | 2003-03-27 | — | — | US | disclosed |
| EP-1285947-A1 | ANTIMICROBIAL COMPOSITION | KURARAY CO., LTD. (JP) | 2003-02-26 | — | — | EP | disclosed |
| US-6512068-B1 | Substantially transparent adhesive composition for hard tissue, and a method for producing it; the adhesive composition exhibits good adhesiveness to hard tissue, especially to both enamel and dentin, and has the advantage of | KURARAY CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1270688-A1 | FILLINGS AND COMPOSITE DENTAL MATERIALS CONTAINING THE FILLINGS | KURARAY CO., LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-20020198284-A1 | Adhesive composition | KURARAY CO. LTD, (JP) | 2002-12-26 | — | — | US | disclosed |
| EP-1262530-A1 | ADHESIVE COMPOSITION | KURARAY CO., LTD. (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6337357-B1 | MICROBIOCIDES, SOLVENTS, CARRIES AND DENTISTRY | KURARAY CO., LTD. (JP) | 2002-01-08 | — | — | US | disclosed |
| EP-1057468-A1 | Adhesive composition and method for producing it | KURARAY CO., LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0980682-A1 | Bonding compositions for dental use | KURARAY CO., LTD. (JP) | 2000-02-23 | — | — | EP | disclosed |
| EP-0865785-A2 | Antimicrobial caries-detecting composition | KURARAY CO., LTD. (JP) | 1998-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240074946-A1 | DENTAL COMPOSITION | PIEZO1, TAS2R42, EIF2B3 | ACHE 4494/4885TSHR 3861/4885POLB 589/4885 |
| US-20240139078-A1 | DENTAL FILLING KIT | DHX29, DHX35, DHX15 | ACHE 1436/4885TSHR 4803/4885POLB 499/4885 |
| US-20240091107-A1 | DENTAL COMPOSITION | CCT7, TAS2R42, CCT5 | ACHE 4152/4885TSHR 3718/4885POLB 684/4885 |
| US-20240074945-A1 | CURABLE COMPOSITION FOR DENTAL RESTORATION | SMCHD1, WDR26, KAT6A | ACHE 3298/4885TSHR 3667/4885POLB 818/4885 |
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | MSL1, ITGA1, ASH2L | ACHE 3124/4885TSHR 4172/4885POLB 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.