Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.58 |
| ▸ | JAK3 | P52333 | 8/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.51 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874932 | 0.88 | JAK2 (0.56) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL3454379 | 0.82 | AIMP2 (0.56) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL14024424 | 0.79 | JAK2 (0.51) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL4779158 | 0.79 | CSF1R (0.51) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL14048207 | 0.76 | KDR (0.65) | JAK2JAK3KDRCYP3A4CYP2C9 | |
| SCHEMBL4297933 | 0.76 | KDR (0.56) | KDRPIK3CAMTORCYP3A4CYP2C9 | |
| SCHEMBL4732552 | 0.75 | KDR (0.75) | KDR | |
| SCHEMBL14024633 | 0.75 | KDR (0.45) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL15888417 | 0.74 | JAK2 (0.45) | JAK2JAK3CSF1RTYK2TBK1 | |
| SCHEMBL14024705 | 0.74 | KDR (0.65) | JAK2JAK3KDRCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154967-A1 | PYRIMIDINE DERIVATIVES | Hutchison Medipharma Enterprises Limited (BS) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008128231-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2008-10-23 | — | — | WO | disclosed |