Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874932 | 0.79 | JAK2 (0.56) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL3456047 | 0.79 | JAK2 (0.58) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL4726143 | 0.76 | AURKA (0.56) | CSF1RJAK2JAK3KDRPIK3CA | |
| SCHEMBL14292806 | 0.76 | SYK (0.55) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL14292522 | 0.76 | SYK (0.55) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL14292069 | 0.76 | SYK (0.55) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL14292759 | 0.76 | AURKA (0.59) | PLK4SYK | |
| SCHEMBL14024424 | 0.75 | JAK2 (0.51) | CSF1RTYK2ULK2TBK1JAK2 | |
| SCHEMBL4795281 | 0.75 | KDR (0.47) | KDRPLK4 | |
| SCHEMBL14292524 | 0.74 | FAAH (0.53) | KDRADRB3MTORSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |