⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15644380 | 0.91 | CYP1A2 (0.31) | — | |
| SCHEMBL2481870 | 0.89 | CYSLTR2 (0.32) | — | |
| SCHEMBL702655 | 0.81 | PRSS1 (0.33) | — | |
| SCHEMBL28550618 | 0.80 | CYP24A1 (0.31) | — | |
| SCHEMBL706845 | 0.77 | KCNH2 (0.33) | — | |
| Bromide SCHEMBL7471970 | 0.76 | HIF1A (0.46) | — | |
| SCHEMBL28549733 | 0.76 | MEN1 (0.30) | — | |
| SCHEMBL2008257 | 0.76 | MEN1 (0.30) | — | |
| SCHEMBL6599889 | 0.75 | MIF (0.38) | — | |
| SCHEMBL15643948 | 0.75 | PTGS2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256107-A1 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | Wyeth LLC (US) | 2010-12-01 | — | — | EP | disclosed |
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| US-7423158-B2 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-20070072925-A1 | Amino-5-[4-(difluoromehtoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase | WYETH (US) | 2007-03-29 | — | — | US | disclosed |