Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.80 |
| ▸ | ADRA1D | P25100 | 20/20 | 0.80 |
| ▸ | HTR1B | P28222 | 20/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.80 |
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7718561 | 0.99 | HTR1A (0.79) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6990832 | 0.89 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7719441 | 0.88 | HTR1A (0.98) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7722195 | 0.88 | HTR1A (0.77) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL13934452 | 0.87 | HTR1A (0.78) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6996368 | 0.87 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6995160 | 0.87 | HTR1A (0.88) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7718490 | 0.86 | HTR1A (0.86) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7719641 | 0.86 | HTR1A (0.98) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7718485 | 0.86 | HTR1A (0.86) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266570-A1 | Use of binding partners for 5-HT5 receptors for treating neurodegenerative and neuropsychiatric disorders | Abbott GmbH & Co. KG (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1143975-A1 | USE OF 5-HT5-LIGANDS IN THE TREATMENT OF NEURODEGENERATIVE AND NEUROPSYCHIATRIC DISTURBANCES | Basf Aktiengesellschaft (DE) | 2001-10-17 | — | — | EP | disclosed |
| EP-1144050-A2 | BINDING PARTNERS FOR 5-HT5-RECEPTORS FOR THE TREATMENT OF MIGRAINE | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041472-A2 | BINDING PARTNERS FOR 5-HT5-RECEPTORS FOR THE TREATMENT OF MIGRAINE | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |
| WO-2000041696-A1 | USE OF 5-HT5-LIGANDS IN THE TREATMENT OF NEURODEGENERATIVE AND NEUROPSYCHIATRIC DISTURBANCES | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-20 | — | — | WO | disclosed |