Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 19/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.58 |
| ▸ | MMP2 | P08253 | 15/20 | 0.58 |
| ▸ | MMP9 | P14780 | 10/20 | 0.50 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175259 | 1.00 | ADAM10 (0.58) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2173994 | 0.93 | ADAM10 (0.49) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2175553 | 0.91 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2176051 | 0.89 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2173570 | 0.88 | ADAM10 (0.60) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2172930 | 0.86 | ADAM10 (0.52) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2173399 | 0.85 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457485 | 0.85 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2176236 | 0.85 | ADAM10 (0.54) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457288 | 0.85 | ADAM10 (0.54) | ADAM10ERBB2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | claimed |