Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 17/20 | 0.51 |
| ▸ | MMP2 | P08253 | 14/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.51 |
| ▸ | MMP9 | P14780 | 7/20 | 0.51 |
| ▸ | MMP3 | P08254 | 4/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.47 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172593 | 1.00 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3457433 | 1.00 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2177605 | 0.88 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3458252 | 0.88 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3458250 | 0.88 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2428637 | 0.86 | ADAM10 (0.54) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL6498128 | 0.86 | ADAM10 (0.54) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2173573 | 0.85 | ADAM10 (0.53) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2177113 | 0.84 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3457422 | 0.84 | ADAM10 (0.51) | ADAM10MMP2ERBB2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |