Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 19/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.64 |
| ▸ | MMP2 | P08253 | 18/20 | 0.64 |
| ▸ | MMP9 | P14780 | 11/20 | 0.60 |
| ▸ | MMP3 | P08254 | 6/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457594 | 1.00 | ADAM10 (0.64) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2171702 | 1.00 | ADAM10 (0.64) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2173799 | 0.92 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2175009 | 0.84 | ADAM10 (0.67) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457598 | 0.84 | ADAM10 (0.69) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2172461 | 0.82 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457380 | 0.82 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457377 | 0.82 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL27651587 | 0.82 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2176705 | 0.82 | ADAM10 (0.72) | ADAM10ERBB2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |