⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418239 | 0.88 | — | — | |
| SCHEMBL15672214 | 0.87 | — | — | |
| SCHEMBL28846384 | 0.82 | CPT1A (0.35) | — | |
| SCHEMBL3477981 | 0.75 | — | — | |
| SCHEMBL2420842 | 0.75 | — | — | |
| SCHEMBL3211235 | 0.73 | KDM4E (0.33) | — | |
| SCHEMBL577222 | 0.71 | — | — | |
| SCHEMBL28557292 | 0.71 | — | — | |
| SCHEMBL7570812 | 0.71 | — | — | |
| SCHEMBL28562666 | 0.71 | MMP9 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523468-B1 | Silicone imides | SIEMENS AG (DE) | 1996-10-09 | — | — | EP | claimed |
| CN-107075147-A | Surface treated filler for ventilated membrane | 欧米亚国际集团 | 2017-08-18 | — | — | CN | disclosed |
| US-7820669-B2 | 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2010-10-26 | — | — | US | disclosed |
| US-20090131448-A1 | 2-(Piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors | NYCOMED GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-7494990-B2 | 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2009-02-24 | — | — | US | disclosed |
| US-20080227790-A1 | Pyridazinone Derivatives and their Use as Pde4 Inhibitors | ALTANA PHARMA AG (DE) | 2008-09-18 | — | — | US | disclosed |
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-20070179146-A1 | 2-(Piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors | ATLANTA PHARMA AG (DE) | 2007-08-02 | — | — | US | disclosed |
| EP-1716133-A1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| EP-1716123-A1 | PYRIDAZINONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005075437-A1 | PYRIDAZINONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005075456-A1 | 2-(PIPERIDIN-4-YL) -4, 5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | WO | disclosed |
| US-4266962-A | USING AMINE SALTS OF P-ALKYLBENZENESULFONIC ACID AS FOAMING AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1981-05-12 | — | — | US | disclosed |