Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 13/20 | 0.66 |
| ▸ | MMP2 | P08253 | 9/20 | 0.66 |
| ▸ | MMP8 | P22894 | 1/20 | 0.66 |
| ▸ | MMP12 | P39900 | 1/20 | 0.66 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458057 | 1.00 | ADAM10 (0.66) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2173575 | 1.00 | ADAM10 (0.66) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2175156 | 0.86 | ADAM10 (0.61) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2174092 | 0.86 | ADAM10 (0.53) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2174077 | 0.85 | ADAM10 (0.65) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL3457938 | 0.85 | ADAM10 (0.65) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL3457943 | 0.85 | ADAM10 (0.65) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2175214 | 0.83 | ADAM10 (0.57) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2172740 | 0.82 | ADAM10 (0.79) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2172733 | 0.82 | ADAM10 (0.79) | ADAM10MMP2MMP8MMP12ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |