Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 13/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.56 |
| ▸ | MMP2 | P08253 | 11/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174893 | 1.00 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL3458394 | 1.00 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172796 | 1.00 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172947 | 0.92 | ADAM10 (0.60) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174013 | 0.92 | ADAM10 (0.60) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2173968 | 0.86 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2422925 | 0.82 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL6024779 | 0.82 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174203 | 0.82 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172745 | 0.82 | ADAM10 (0.77) | ADAM10ERBB2MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | claimed |