Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 19/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.65 |
| ▸ | MMP2 | P08253 | 16/20 | 0.58 |
| ▸ | MMP9 | P14780 | 8/20 | 0.52 |
| ▸ | MMP3 | P08254 | 6/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171932 | 1.00 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2175233 | 0.91 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2174503 | 0.90 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2174929 | 0.90 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2172579 | 0.87 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457984 | 0.82 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL6024732 | 0.82 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2174553 | 0.82 | ADAM10 (0.71) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3458731 | 0.82 | ADAM10 (0.72) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2175909 | 0.82 | ADAM10 (0.72) | ADAM10ERBB2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | claimed |