Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27201665 | 1.00 | HTR2A (0.51) | HTR2AHTR2CDRD2DRD3KCNH2 | |
| SCHEMBL27841195 | 0.89 | HTR2C (0.49) | HTR2AHTR2C | |
| SCHEMBL9773283 | 0.89 | HTR2C (0.49) | HTR2AHTR2C | |
| SCHEMBL27821867 | 0.89 | HTR2C (0.49) | HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL31278837 | 0.87 | HTR2C (0.49) | HTR2AHTR2C | |
| SCHEMBL22132292 | 0.83 | HTR2A (0.47) | HTR2AHTR2CDRD2DRD3KCNH2 | |
| SCHEMBL22136718 | 0.83 | HTR2C (0.50) | HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL2145272 | 0.79 | HTR6 (0.45) | HTR2ADRD2DRD3HTR6 | |
| SCHEMBL6173955 | 0.79 | IKBKB (0.44) | HTR2AHTR2CDRD2DRD3KCNH2 | |
| SCHEMBL15830285 | 0.79 | HTR2C (0.62) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261224-A2 | 6-(Pyridinyl)-4-pyrimidone derivatives as tau protein kinase 1 inhibitors | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-12-15 | — | — | EP | disclosed |