Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608601 | 1.00 | MEN1 (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL112086 | 1.00 | MEN1 (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL33643 | 0.95 | MEN1 (0.36) | MEN1KMT2ATDP1 | |
| SCHEMBL1817908 | 0.95 | MEN1 (0.31) | MEN1KMT2ATDP1 | |
| SCHEMBL14419071 | 0.90 | — | — | |
| SCHEMBL24732508 | 0.90 | MEN1 (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL3412014 | 0.90 | MEN1 (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL1336247 | 0.90 | MEN1 (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL9907096 | 0.89 | — | — | |
| SCHEMBL9301852 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4795755-A | ANTISECRETORY, ANTIULCER AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-03 | — | — | US | claimed |
| US-4762932-A | Haloguanidine intermediates | IMPERIAL CHEMICAL INDUSTRIES, LTD. (GB) | 1988-08-09 | — | — | US | claimed |
| US-4746672-A | HISTAMINE H-2 ANTAGONISTS WHICH INHIBIT GASTRIC ACID SECRETION | ICI AMERICAS INC. (US) | 1988-05-24 | — | — | US | claimed |
| US-4683228-A | Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion | ICI AMERICAS INC. (US) | 1987-07-28 | — | — | US | claimed |
| US-4657908-A | Carbonyl derivatives | ICI AMERICAS, INC. (US) | 1987-04-14 | — | — | US | claimed |
| EP-0060697-B1 | HETEROCYCLIC DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-12-30 | — | — | EP | claimed |
| US-4604465-A | Haloguanidine intermediates | ICI AMERICAS, INC. (US) | 1986-08-05 | — | — | US | claimed |
| EP-0059597-B1 | GUANIDINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES HAVING HISTAMINE H-2 ANTAGONIST ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-04-23 | — | — | EP | claimed |
| US-4570000-A | HISTAMINE HH-2 ANTAGONISTS; GASTROINTESTINAL DISORDERS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1986-02-11 | — | — | US | claimed |
| EP-0060094-B1 | GUANIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-22 | — | — | EP | claimed |
| US-4362728-A | Haloguanidine compounds, pharmaceutical compositions and methods of use | ICI AMERICAS INC. (US) | 1982-12-07 | — | — | US | claimed |
| EP-0065823-A1 | Heterocyclic guanidines as histamine H-2 antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-01 | — | — | EP | claimed |
| EP-0061318-A2 | Guanidinoheterocyclic derivatives as histamine H-2 antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-29 | — | — | EP | claimed |
| EP-0060697-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | claimed |
| EP-0060696-A1 | Nitrogen heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | claimed |
| EP-0060730-A2 | Bicyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | claimed |
| EP-0060094-A2 | Guanidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-15 | — | — | EP | claimed |
| EP-0059597-A2 | Guanidino-substituted heterocyclic derivatives having histamine H-2 antagonist activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-08 | — | — | EP | claimed |
| EP-0045155-A1 | Guanidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-02-03 | — | — | EP | claimed |
| EP-0030092-A1 | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-06-10 | — | — | EP | claimed |