Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 1.00 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.62 |
| ▸ | ABAT | P80404 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3,4-Dihydroxy-5-Nitrobenzaldehyde SCHEMBL29357099 | 1.00 | XDH (1.00) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| 3,4-Dihydroxy-5-Nitrobenzaldehyde SCHEMBL8731720 | 0.98 | XDH (0.96) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| 3,4-Dihydroxy-5-Nitrobenzaldehyde SCHEMBL28213417 | 0.96 | XDH (0.93) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL6897071 | 0.90 | XDH (0.81) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL532580 | 0.85 | XDH (0.74) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL15783651 | 0.83 | XDH (0.71) | XDHALDH5A1ABAT | |
| SCHEMBL16838205 | 0.83 | XDH (0.71) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL14492368 | 0.82 | XDH (0.70) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL7243507 | 0.82 | XDH (0.70) | XDHALDH5A1ABATMEN1ALDH1A1 | |
| SCHEMBL531545 | 0.81 | XDH (0.69) | XDHALDH5A1ABATMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 498 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016743-A1 | A METHOD FOR PRODUCING ENTACAPONE TABLETS | CHINA MEHECO KANGLI PHARMA CO., LTD. (CN) | 2024-01-18 | — | — | US | claimed |
| US-20230346765-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-02 | — | — | US | claimed |
| CN-113109465-B | Quality detection method and application of entacapone | 海南通用康力制药有限公司 | 2023-04-07 | — | — | CN | claimed |
| EP-4121052-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | Baylor College of Medicine (US) | 2023-01-25 | — | — | EP | claimed |
| CN-109336800-B | DHNB (dehydroepiandrosterone) condensed phenylthiosemicarbazide compound as well as preparation method and application thereof | 江西中医药大学 | 2022-11-29 | — | — | CN | claimed |
| WO-2022205574-A1 | METHOD FOR PRODUCING ENTACAPONE TABLETS | 海南通用康力制药有限公司 | 2022-10-06 | — | — | WO | claimed |
| CN-113481725-A | Preparation method of medical antibacterial non-woven fabric | 上海蟠龙医用材料有限公司 | 2021-10-08 | — | — | CN | claimed |
| CN-112680877-B | Antibacterial non-woven fabric and preparation process thereof | 浙江雅宝无纺布制品有限公司 | 2021-10-01 | — | — | CN | claimed |
| WO-2021188296-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2021-09-23 | — | — | WO | claimed |
| CN-109875988-B | Synthesis of compound DHNB semicarbazone and application of compound DHNB semicarbazone in preventing and treating gout and hyperuricemia | 江西中医药大学 | 2021-08-27 | — | — | CN | claimed |
| EP-0782559-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORIONYHTYMÄ OY (FI) | 1997-07-09 | — | — | EP | claimed |
| EP-0444899-B1 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION YHTYMAE OY (FI) | 1997-02-05 | — | — | EP | claimed |
| EP-0589948-B1 | METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | ORION YHTYMAE OY (FI) | 1996-09-04 | — | — | EP | claimed |
| WO-1996009274-A1 | NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | Orion-Yhtymä Oy (FI) | 1996-03-28 | — | — | WO | claimed |
| US-5382699-A | Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde | ORION-YHTYMA OY (FI) | 1995-01-17 | — | — | US | claimed |
| EP-0589948-A1 | METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE. | ORION YHTYMAE OY (FI) | 1994-04-06 | — | — | EP | claimed |
| EP-0323162-B1 | NEW USE OF CATECHOL-O-METHYL TRANSFERASE (COMT) INHIBITORS AND THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS AND ESTERS | ORION YHTYMAE OY (FI) | 1993-09-15 | — | — | EP | claimed |
| WO-1993000323-A1 | METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | Orion-Yhtymä Oy (FI) | 1993-01-07 | — | — | WO | claimed |
| EP-0444899-A2 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION-YHTYMÀ OY (FI) | 1991-09-04 | — | — | EP | claimed |
| EP-0323162-A2 | New use of catechol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters | ORION-YHTYMÀ OY (FI) | 1989-07-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346765-A1 | METHODS OF TREATING XANTHINE OXIDASE-RELATED DISEASES WITH NIFLUMIC ACID AND DERIVATIVES THEREOF | XDH, PNPO, PNP | XDH 1/4885ALDH5A1 51/4885ABAT 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.