Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 10/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947088 | 0.94 | SMN1; SMN2 (0.41) | MAPK8MAPK9PRKD3SYKALDH1A1 | |
| SCHEMBL965756 | 0.93 | MAPK8 (0.41) | MAPK8MAPK9PRKD3ALDH1A1KMT2A | |
| SCHEMBL3460097 | 0.91 | MAPK8 (0.40) | MAPK8MAPK9PRKD3SYKALDH1A1 | |
| SCHEMBL968349 | 0.90 | MAPK8 (0.41) | MAPK8MAPK9PRKD3ALDH1A1KMT2A | |
| SCHEMBL968116 | 0.90 | MAPK8 (0.39) | MAPK8MAPK9PRKD3SYKALDH1A1 | |
| SCHEMBL3461155 | 0.89 | MAPK8 (0.44) | MAPK8MAPK9PRKD3ALDH1A1KMT2A | |
| SCHEMBL963869 | 0.89 | MAPK8 (0.39) | MAPK8MAPK9PRKD3SYKALDH1A1 | |
| SCHEMBL968604 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9PRKD3ALDH1A1KMT2A | |
| SCHEMBL968602 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9PRKD3ALDH1A1KMT2A | |
| SCHEMBL968112 | 0.86 | MAPK8 (0.37) | MAPK8MAPK9PRKD3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |