Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 11/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RPS27 | P42677 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459373 | 0.93 | MAPK8 (0.42) | MAPK8MAPK9PRKD3MEN1ALDH1A1 | |
| SCHEMBL3461151 | 0.93 | MAPK8 (0.44) | MAPK8MAPK9PRKD3MAPK10MEN1 | |
| SCHEMBL3460056 | 0.91 | SMN1; SMN2 (0.40) | MEN1ALDH1A1POLBKMT2ACTSL | |
| SCHEMBL965756 | 0.90 | MAPK8 (0.41) | MAPK8MAPK9PRKD3MAPK10MEN1 | |
| SCHEMBL3459877 | 0.90 | MAPK8 (0.41) | MAPK8MAPK9MEN1ALDH1A1POLB | |
| SCHEMBL10180401 | 0.90 | RXFP1 (0.44) | ALDH1A1KMT2ACTSLCTSBCTSK | |
| SCHEMBL3460790 | 0.89 | MAPK8 (0.41) | MAPK8MAPK9PRKD3MAPK10MEN1 | |
| SCHEMBL3460097 | 0.88 | MAPK8 (0.40) | MAPK8MAPK9PRKD3MAPK10MEN1 | |
| SCHEMBL968116 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9PRKD3MAPK10MEN1 | |
| SCHEMBL3459370 | 0.87 | ALDH1A1 (0.43) | MAPK8MAPK9PRKD3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | claimed |