SCHEMBL346177

SCHEMBL346177

[O]C1=C2C=CC=CN2C=CC1

nearest known ligand 0.30

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
CASP1 P29466 1/20 0.30
CASP7 P55210 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6423801 0.77
SCHEMBL11312340 0.75
SCHEMBL13865281 0.75
SCHEMBL5361784 0.75
SCHEMBL19895294 0.75
SCHEMBL6752103 0.73 PYGM (0.34)
SCHEMBL5349801 0.73
SCHEMBL6756889 0.72 PYGM (0.33)
SCHEMBL19952738 0.71
SCHEMBL9693364 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4214200-A1 LANCL LIGANDS Nimmune Biopharma, Inc. (US) 2023-07-26 EP disclosed
CN-113748109-B Lanthionine C-like protein 2 ligands, cells prepared with said ligands and therapies using said ligands 朗多生物制药股份有限公司 2023-07-21 CN disclosed
CN-116368133-A NLRX1 ligand 朗多生物制药股份有限公司 2023-06-30 CN disclosed
US-20230167083-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2023-06-01 US disclosed
US-11459310-B2 LANCL ligands LANDOS BIOPHARMA, INC. (US) 2022-10-04 US disclosed
WO-2022087146-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2022-04-28 WO disclosed
US-20220127250-A1 LANCL LIGANDS LANDOS BIOPHARMA, INC. (US) 2022-04-28 US disclosed
CN-113748109-A Lanthionine C-like protein 2 ligands, cells prepared with said ligands and therapies using said ligands 朗多生物制药股份有限公司 2021-12-03 CN disclosed
EP-2266978-B1 Novel physiologically active substances EISAI R&D MAN CO LTD (JP) 2015-05-20 EP disclosed
EP-1548121-B1 Physiologically active substances EISAI R&D MAN CO LTD (JP) 2015-04-29 EP disclosed
US-20060241171-A1 Novel physiologically active substances MICROBIOPHARM JAPAN CO., LTD. (JP) 2006-10-26 US disclosed
US-20060235002-A1 Novel physiologically active substance EISAI R&D MANAGEMENT CO., LTD. (JP) 2006-10-19 US disclosed
EP-1710244-A1 METHOD OF STABILIZING MACROLIDE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2006-10-11 EP disclosed
EP-1705247-A1 DNA PARTICIPATING IN HYDROXYLATION OF MACROLIDE COMPOUND MERCIAN CORPORATION (JP) 2006-09-27 EP disclosed
US-20060009439-A1 Novel physiologically active substances MERCIAN CORPORATION (JP) 2006-01-12 US disclosed
US-20050245514-A1 Novel physiologically active substances MICROBIOPHARM JAPAN CO., LTD. (JP) 2005-11-03 US disclosed
US-20050227959-A1 Heterocyclic compound having oxime group EISAI CO., LTD. (JP) 2005-10-13 US disclosed
EP-1548121-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-06-29 EP disclosed
EP-1541570-A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE MERCIAN CORPORATION (JP) 2005-06-15 EP disclosed
EP-1508570-A1 NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES MERCIAN CORPORATION (JP) 2005-02-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050245514-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA KDM4E 4239/4885MEN1 2091/4885ALDH1A1 133/4885
US-20220127250-A1 LANCL LIGANDS LANCL2, LANCL1, LCLAT1 KDM4E 3554/4885MEN1 473/4885ALDH1A1 4156/4885
US-20060241171-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA KDM4E 3533/4885MEN1 2851/4885ALDH1A1 108/4885
US-20060009439-A1 Novel physiologically active substances HIF1A, HIF1AN, VEGFA KDM4E 3533/4885MEN1 2851/4885ALDH1A1 108/4885
US-20060235002-A1 Novel physiologically active substance HIF1AN, HIF1A, VEGFA KDM4E 3844/4885MEN1 2966/4885ALDH1A1 119/4885
US-11459310-B2 LANCL ligands LANCL2, LANCL1, ACSL1 KDM4E 3796/4885MEN1 364/4885ALDH1A1 3541/4885
US-20050227959-A1 Heterocyclic compound having oxime group STAT6, HRH4, HRH2 KDM4E 855/4885MEN1 3783/4885ALDH1A1 1391/4885
US-20230167083-A1 LANCL LIGANDS LANCL2, LANCL1, LCLAT1 KDM4E 3554/4885MEN1 473/4885ALDH1A1 4156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.