Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 6/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462788 | 0.94 | TYRO3 (0.52) | TYRO3KIFC1ATRHTR2CNTRK1 | |
| SCHEMBL3461080 | 0.92 | TYRO3 (0.50) | TYRO3KIFC1CHEK1ATRNTRK1 | |
| SCHEMBL3460381 | 0.91 | TYRO3 (0.49) | TYRO3ROCK2PKN2CHEK1ATR | |
| SCHEMBL3459910 | 0.91 | ROCK2 (0.50) | TYRO3CHEK2METROCK2PKN2 | |
| SCHEMBL3462144 | 0.90 | TYRO3 (0.48) | TYRO3ROCK2PKN2ATRNTRK1 | |
| SCHEMBL3462047 | 0.90 | TYRO3 (0.51) | TYRO3KIFC1CHEK1ATRNTRK1 | |
| SCHEMBL3459997 | 0.89 | TYRO3 (0.55) | TYRO3CHEK2METKIFC1CHRM3 | |
| SCHEMBL3460676 | 0.89 | ATR (0.50) | TYRO3ROCK2PKN2ATR | |
| SCHEMBL3461431 | 0.88 | TYRO3 (0.48) | TYRO3CHEK2METROCK2PKN2 | |
| SCHEMBL3462278 | 0.88 | TYRO3 (0.48) | TYRO3CHEK2METROCK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | TYRO3 790/4885CHEK2 61/4885MET 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.