Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 18/20 | 0.64 |
| ▸ | MMP2 | P08253 | 14/20 | 0.64 |
| ▸ | MMP8 | P22894 | 1/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174742 | 1.00 | ADAM10 (0.64) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2174843 | 0.99 | ADAM10 (0.63) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2174082 | 0.90 | ADAM10 (0.53) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL27651622 | 0.88 | ADAM10 (0.60) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL3456976 | 0.88 | ADAM10 (0.60) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL3457144 | 0.85 | ADAM10 (0.65) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL6336101 | 0.84 | ADAM10 (0.67) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL6336103 | 0.84 | ADAM10 (0.67) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL6344361 | 0.84 | ADAM10 (0.67) | ADAM10MMP2MMP8MMP12ADAM17 | |
| SCHEMBL2172021 | 0.80 | ADAM10 (0.57) | ADAM10MMP2MMP8MMP12ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |