Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CHRH1HRH2
The experimentally established mechanism targets of Tolazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.76 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.76 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.76 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.76 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.76 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.76 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | HTR1B | P28222 | 4/20 | 0.56 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 5/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolazoline SCHEMBL3463648 | 0.91 | TAAR1 (0.76) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL34961 | 0.87 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL28254903 | 0.85 | TAAR1 (0.96) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL5053858 | 0.85 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL34869 | 0.85 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL9614505 | 0.85 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL9221347 | 0.84 | TAAR1 (0.81) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL28268861 | 0.83 | TAAR1 (0.78) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Phthalic Acid SCHEMBL28266376 | 0.82 | TAAR1 (0.76) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL27969662 | 0.81 | TAAR1 (0.73) | TAAR1CYP2D6ADRA2AADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080116076-A1 | METHOD AND COMPOSITION FOR DIRECT METALLIZATION OF NON-CONDUCTIVE SUBSTRATES | ENTHONE INC. (US) | 2008-05-22 | — | — | US | claimed |
| US-8330039-B2 | Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-11 | — | — | US | disclosed |
| CN-102292826-A | Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound | — | 2011-12-21 | — | — | CN | disclosed |
| US-20100180947-A1 | SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-07-22 | — | — | US | disclosed |
| US-20080116076-A1 | METHOD AND COMPOSITION FOR DIRECT METALLIZATION OF NON-CONDUCTIVE SUBSTRATES | ENTHONE INC. (US) | 2008-05-22 | — | — | US | disclosed |
| US-20030013830-A1 | Reacting a thiosulfate salt with a halogenated styrenic monomer to form a styrenic thiosulfate salt monomer and then polymerization of said monomer in the presence of an initiator | BLEVINS RICHARD W (US) | 2003-01-16 | — | — | US | disclosed |
| US-6420505-B1 | STYRENE THIOSULFATE AND OLEFIN MONOMER | EASTMAN KODAK COMPANY | 2002-07-16 | — | — | US | disclosed |