Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CHRH1HRH2
The experimentally established mechanism targets of Tolazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.96 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.96 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.96 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.96 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.96 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.96 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.73 |
| ▸ | MAOA | P21397 | 2/20 | 0.73 |
| ▸ | MAOB | P27338 | 2/20 | 0.73 |
| ▸ | HTR1D | P28221 | 5/20 | 0.66 |
| ▸ | HTR1B | P28222 | 4/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolazoline SCHEMBL5053858 | 1.00 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL9614505 | 1.00 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL34961 | 0.98 | TAAR1 (1.00) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL28254903 | 0.96 | TAAR1 (0.96) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL11170308 | 0.89 | TAAR1 (0.80) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL9221347 | 0.88 | TAAR1 (0.81) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| SCHEMBL11597510 | 0.87 | TAAR1 (0.79) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL28268861 | 0.87 | TAAR1 (0.78) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL3463645 | 0.85 | TAAR1 (0.76) | TAAR1CYP2D6ADRA2AADRA2CADRA1A | |
| Tolazoline SCHEMBL3463648 | 0.85 | TAAR1 (0.76) | TAAR1CYP2D6ADRA2AADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1377 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118169271-A | Method for detecting alpha-adrenergic receptor blocker, SSRI and 5-ARIs and application thereof | 巴中市产品质量检验检测中心 | 2024-06-11 | — | — | CN | claimed |
| US-20170128379-A1 | MODIFIED RELEASE PHARMACEUTICAL PREPARATIONS | RUBICON RESEARCH PRIVATE LIMITED (IN) | 2017-05-11 | — | — | US | claimed |
| WO-2016001937-A2 | MODIFIED RELEASE PHARMACEUTICAL PREPARATIONS | RUBICON RESEARCH PRIVATE LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| CN-103479579-A | Industrialized production of liposome combination medicine by molecular dispersion method, and quality control technology | CAI HAIDE | 2014-01-01 | — | — | CN | claimed |
| CN-103446054-A | Liposome combination drugs, industrial production process of liposome combination drug through molecular dispersion method, and quality control | CAI HAIDE | 2013-12-18 | — | — | CN | claimed |
| CN-102885798-A | Orally disintegrating tablet | CHENGDU KANGHONG PHARMACEUTICAL GROUP CO LTD | 2013-01-23 | — | — | CN | claimed |
| US-8268352-B2 | Modified release composition for highly soluble drugs | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-18 | — | — | US | claimed |
| US-8263125-B2 | Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-11 | — | — | US | claimed |
| CN-102218038-A | Formula, preparation method and application of tolazoline hydrochloride liposome combination medicine | XUEFENG DENG | 2011-10-19 | — | — | CN | claimed |
| CN-101912363-A | Dissolving ultrafiltration-spray drying-molecule dispersion coating-hydration palletizing-freeze drying method for preparing liposome combination medicine | HAIDE CAI | 2010-12-15 | — | — | CN | claimed |
| EP-0729748-A1 | PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION, AND PHARMACEUTICAL PREPARATION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-09-04 | — | — | EP | claimed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| US-5457486-A | Thermal printing | XEROX CORPORATION (US) | 1995-10-10 | — | — | US | claimed |
| US-5399581-A | Method and compositions for treatment of sexual impotence | LARAGH JOHN H (US) | 1995-03-21 | — | — | US | claimed |
| EP-0615856-A1 | Recording sheets containing tetrazolium, indolinium, imidazole and imidazolinium compounds | XEROX CORPORATION (US) | 1994-09-21 | — | — | EP | claimed |
| US-5328453-A | Method for enhancing transdermal drug delivery of electrical drug applicators | DRUG DELIVERY SYSTEMS INC. (US) | 1994-07-12 | — | — | US | claimed |
| US-5196432-A | Mechanism mediating ruminal stasis in ruminal lactic acidosis | CRICHLOW EUGENE C (CA) | 1993-03-23 | — | — | US | claimed |
| WO-1992011851-A1 | METHOD AND COMPOSITIONS FOR TREATMENT OF SEXUAL IMPOTENCE | LARAGH JOHN H (US) | 1992-07-23 | — | — | WO | claimed |
| US-4933213-A | Crosslinking process | SOCIETE CHIMIQUE DES CHARBONNAGES S.A. (FR) | 1990-06-12 | — | — | US | claimed |
| US-4127118-A | Method of effecting and enhancing an erection | ELSA LATORRE, EXECUTRIX | 1978-11-28 | — | — | US | claimed |