Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 7/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.43 |
| ▸ | F7 | P08709 | 7/20 | 0.43 |
| ▸ | F10 | P00742 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | F3 | P13726 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13163044 | 0.95 | ALDH1A1 (0.51) | ALDH1A1HTTF2PRSS1F7 | |
| Trifluoroacetic Acid SCHEMBL3464956 | 0.90 | F7 (0.47) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL3463552 | 0.88 | F7 (0.46) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL3464911 | 0.88 | F2 (0.46) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL3463948 | 0.87 | F7 (0.48) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL3464775 | 0.86 | F7 (0.44) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL4911664 | 0.85 | F2 (0.44) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL13163045 | 0.85 | F7 (0.49) | ALDH1A1F2PRSS1F7F10 | |
| Trifluoroacetic Acid SCHEMBL3464509 | 0.84 | PRSS1 (0.46) | F2PRSS1F7F10PRSS2 | |
| SCHEMBL13162829 | 0.83 | F7 (0.52) | ALDH1A1F2PRSS1F7F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240654-A1 | HYDRAZIDE DERIVATIVES | CLARK RICHARD | 2010-09-23 | — | — | US | disclosed |
| US-20080132507-A1 | Hydrazide Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-06-05 | — | — | US | disclosed |
| EP-1810965-A1 | HYDRAZIDE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2007-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240654-A1 | HYDRAZIDE DERIVATIVES | H1-10, H1-4, H1-3 | ALDH1A1 192/4885HTT 154/4885F2 19/4885 |
| US-20080132507-A1 | Hydrazide Derivatives | H1-10, H1-4, H1-3 | ALDH1A1 192/4885HTT 154/4885F2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.