Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12240275 | 0.84 | KMT2A (0.53) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6476384 | 0.84 | HTT (0.67) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL22361985 | 0.83 | FFAR1 (0.45) | ALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL11637842 | 0.83 | FFAR1 (0.45) | ALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL8101844 | 0.82 | KMT2A (0.51) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10474462 | 0.81 | HTT (0.58) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10474461 | 0.81 | HTT (0.58) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL12264121 | 0.79 | KMT2A (0.47) | HTTKMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14557234 | 0.79 | ALDH1A1 (0.53) | HTTKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1021140 | 0.79 | HTT (0.59) | HTTKMT2AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | claimed |
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |