⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3465570 | 1.00 | — | — | |
| SCHEMBL3390084 | 0.85 | SPHK1 (0.39) | — | |
| SCHEMBL3390081 | 0.85 | SPHK1 (0.39) | — | |
| SCHEMBL3432736 | 0.84 | — | — | |
| SCHEMBL3387960 | 0.81 | — | — | |
| SCHEMBL3387963 | 0.81 | — | — | |
| SCHEMBL1049767 | 0.81 | — | — | |
| SCHEMBL8580183 | 0.81 | CA2 (0.32) | — | |
| SCHEMBL8580187 | 0.81 | CA2 (0.32) | — | |
| SCHEMBL3389166 | 0.77 | PSMB11 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786307-B2 | suchas N-(4(S)-amino-5(S)-hydroxy-2(S)-isopropyl-6-piperidin-1-ylhexyl)-2-(3-methoxypropoxy)benzamide dihydrochloride, used for the treatment of hypertension, cardiovasculr disorders, complications owing to diabetes, vision deffects, hyperaldosteronism, states of anxiety and cognitive disorders | NOVARTIS AG (CH) | 2010-08-31 | — | — | US | disclosed |
| US-20070155743-A1 | Amino alcohol derivatives and their activity as renin inhibitors | NOVARTIS PHARMA AG (CH) | 2007-07-05 | — | — | US | disclosed |