Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917195 | 0.90 | TP53 (0.57) | HDAC6HDAC3HDAC1MEN1KMT2A | |
| SCHEMBL3467026 | 0.87 | CNR2 (0.51) | HDAC6HDAC3HDAC1TP53CNR2 | |
| SCHEMBL3476785 | 0.86 | TP53 (0.51) | HDAC6HDAC3HDAC1MEN1KMT2A | |
| SCHEMBL3466724 | 0.79 | HDAC6 (0.54) | HDAC6HDAC3HDAC1TP53SMN1; SMN2 | |
| SCHEMBL3468901 | 0.78 | HDAC1 (0.48) | HDAC6HDAC3HDAC1CNR2CNR1 | |
| SCHEMBL7912521 | 0.78 | HDAC3 (0.59) | HDAC6HDAC3HDAC1KMT2ATP53 | |
| SCHEMBL7921598 | 0.78 | HDAC6 (0.55) | HDAC6HDAC3HDAC1TP53SMN1; SMN2 | |
| SCHEMBL3467874 | 0.77 | HDAC6 (0.57) | HDAC6HDAC3HDAC1TP53SMN1; SMN2 | |
| SCHEMBL3466885 | 0.77 | HDAC6 (0.59) | HDAC6HDAC3HDAC1TP53SMN1; SMN2 | |
| SCHEMBL3468139 | 0.77 | CNR2 (0.58) | HDAC6HDAC3HDAC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010073078-A2 | HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-01 | — | — | WO | claimed |
| WO-2010073078-A2 | HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-01 | — | — | WO | disclosed |