SCHEMBL3476785

SCHEMBL3476785

COc1ccc(NC(=O)c2cn(CCCCCC(=O)NO)c3ccc(F)cc3c2=O)c(OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HDAC6 Q9UBN7 2/20 0.51
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.48
GAA P10253 2/20 0.47
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
CNR1 P21554 2/20 0.45
CNR2 P34972 2/20 0.45
POLB P06746 4/20 0.45
RXFP1 Q9HBX9 1/20 0.45
MAPT P10636 4/20 0.44
NPSR1 Q6W5P4 1/20 0.44
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43
TUBB4B P68371 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7917195 0.94 TP53 (0.57) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3467448 0.88 GAA (0.54) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3467483 0.87 GAA (0.60) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3467066 0.86 HDAC6 (0.47) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3466724 0.84 HDAC6 (0.54) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL7912521 0.83 HDAC3 (0.59) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL7921598 0.83 HDAC6 (0.55) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3467960 0.82 HDAC1 (0.51) HDAC6HDAC3HDAC1GAACNR2
SCHEMBL3467874 0.81 HDAC6 (0.57) TP53SMN1; SMN2HDAC6HDAC3HDAC1
SCHEMBL3466885 0.81 HDAC6 (0.59) TP53SMN1; SMN2HDAC6HDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010073078-A2 HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS ORCHID RESEARCH LABORATORIES LTD. (IN) 2010-07-01 WO claimed
WO-2010073078-A2 HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS ORCHID RESEARCH LABORATORIES LTD. (IN) 2010-07-01 WO disclosed