Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.54 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.35 |
| ▸ | CDK1 | P06493 | 8/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.35 |
| ▸ | CDK4 | P11802 | 8/20 | 0.35 |
| ▸ | CCND1 | P24385 | 8/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.35 |
| ▸ | CCND2 | P30279 | 4/20 | 0.32 |
| ▸ | CCND3 | P30281 | 4/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197997 | 0.82 | CDK2 (0.50) | CDK2MYCWDR5CCNE2CCNE1 | |
| SCHEMBL6179556 | 0.74 | CDK2 (0.59) | CDK2MYCWDR5CCNE2CCNE1 | |
| SCHEMBL24867729 | 0.72 | CDK2 (0.33) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL960172 | 0.70 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL9950303 | 0.69 | HDAC3 (0.58) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL1025148 | 0.69 | MYC (0.47) | CDK2MYCWDR5NOS1 | |
| SCHEMBL3467465 | 0.69 | CDK2 (0.76) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL1694571 | 0.68 | CDK2 (0.33) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL6198002 | 0.66 | CDK2 (0.60) | CDK2CCNE2CCNE1CDK1CCNB1 | |
| SCHEMBL16086894 | 0.66 | CDK2 (0.41) | CDK2MYCWDR5NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563741-B2 | CDK inhibitors containing a zinc binding moiety | CURIS, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120165335-A1 | CDK INHIBITORS | CURIS, INC. | 2012-06-28 | — | — | US | disclosed |
| WO-2010075542-A1 | CDK INHIBITORS | CURIS, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20090093507-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2009-04-09 | — | — | US | disclosed |
| WO-2009036016-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093507-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CDK3, CDKL1, CDKL3 | CDK2 17/4885MYC 522/4885WDR5 548/4885 |
| US-20120165335-A1 | CDK INHIBITORS | CDK3, CDK6, CDKL1 | CDK2 7/4885MYC 93/4885WDR5 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.