Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27436341 | 0.81 | GSK3B (0.46) | ALDH1A1KDM4ESMN1; SMN2TDP1MAPT | |
| SCHEMBL2760413 | 0.77 | KDM4E (0.61) | ALDH1A1KDM4ESMN1; SMN2TDP1MAPT | |
| SCHEMBL31661348 | 0.76 | CYP3A4 (0.62) | ALDH1A1KDM4ESMN1; SMN2TDP1CASP1 | |
| SCHEMBL6866139 | 0.76 | CYP3A4 (0.62) | ALDH1A1KDM4ESMN1; SMN2TDP1CASP1 | |
| SCHEMBL23197679 | 0.76 | TDP1 (0.56) | ALDH1A1KDM4ESMN1; SMN2TDP1CASP1 | |
| SCHEMBL13212958 | 0.75 | TDP1 (0.43) | ALDH1A1KDM4ESMN1; SMN2TDP1CASP1 | |
| SCHEMBL3468663 | 0.74 | GSK3B (0.50) | ALDH1A1KDM4ESMN1; SMN2TDP1GSK3B | |
| SCHEMBL15928744 | 0.74 | TDP1 (0.42) | ALDH1A1KDM4ESMN1; SMN2TDP1CASP1 | |
| SCHEMBL1351745 | 0.73 | ALDH1A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2CASP1MAPT | |
| SCHEMBL7832864 | 0.73 | KDM4E (0.45) | ALDH1A1KDM4ESMN1; SMN2TDP1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024133499-A1 | GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2024-06-27 | — | — | WO | disclosed |
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |