Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468249 | 0.76 | CYP4F2 (0.44) | CYP4F2CYP4A11MAPTTHRBMEN1 | |
| SCHEMBL11451516 | 0.74 | HSD17B10 (0.50) | CES1CES2MAPTTHRBHSD17B10 | |
| SCHEMBL9457646 | 0.72 | CES1 (0.45) | CES1CES2MAPTTHRBHSD17B10 | |
| SCHEMBL11084109 | 0.72 | CES1 (0.59) | CES1CES2MAPTTHRBHSD17B10 | |
| SCHEMBL1710113 | 0.71 | CES1 (0.50) | CES1CES2MAPTTHRBHSD17B10 | |
| SCHEMBL5557393 | 0.71 | CYP4F2 (0.72) | CYP4F2CYP4A11MAPTTHRBHSD17B10 | |
| SCHEMBL444076 | 0.70 | CYP4F2 (0.63) | CYP4F2CYP4A11MAPTTHRBHSD17B10 | |
| SCHEMBL20262480 | 0.69 | CYP4F2 (0.53) | CYP4F2CYP4A11THRBHSD17B10POLB | |
| SCHEMBL11706612 | 0.69 | CYP4F2 (0.53) | CYP4F2CYP4A11THRBHSD17B10MEN1 | |
| SCHEMBL14535085 | 0.68 | CES1 (0.55) | CES1CES2MAPTTHRBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144875-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | Amira Pharmaceuticals, Inc. (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137609-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |