Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 6/20 | 0.38 |
| ▸ | MERTK | Q12866 | 6/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469184 | 0.94 | IKBKE (0.41) | IKBKETBK1LRRK2CHRNA7BMPR1B | |
| SCHEMBL3469125 | 0.83 | CHRNA7 (0.43) | IKBKETBK1CHRNA7BMPR1BBMPR1A | |
| SCHEMBL2497147 | 0.81 | BMPR1B (0.40) | LRRK2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL2388397 | 0.80 | AXL (0.56) | IKBKETBK1AXLMERTKDYRK1A | |
| SCHEMBL3469349 | 0.79 | BMPR1B (0.39) | LRRK2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL3469290 | 0.78 | BMPR1B (0.38) | LRRK2BMPR1BBMPR1AACVRL1ACVR1 | |
| Hydrochloric Acid SCHEMBL3469292 | 0.78 | BMPR1B (0.38) | LRRK2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL3469171 | 0.77 | CHRNA7 (0.40) | IKBKETBK1CHRNA7BMPR1BBMPR1A | |
| SCHEMBL2387892 | 0.75 | MERTK (0.57) | IKBKETBK1AXLMERTK | |
| SCHEMBL3470462 | 0.72 | LRRK2 (0.51) | LRRK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |