Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 3/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | PROKR1 | Q8TCW9 | 10/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390911 | 0.94 | SPR (0.63) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2391154 | 0.88 | SPR (0.61) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2393167 | 0.85 | SPR (0.65) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2390029 | 0.85 | SPR (0.58) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2388516 | 0.84 | SPR (0.65) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2386684 | 0.83 | SPR (0.61) | SPRNAMPTHSD11B1ROCK2FASN | |
| SCHEMBL2387825 | 0.82 | NAMPT (0.60) | SPRNAMPTHSD11B1PROKR1CCNC | |
| SCHEMBL2387066 | 0.81 | NAMPT (0.64) | SPRNAMPTHSD11B1ROCK2 | |
| SCHEMBL2388720 | 0.81 | NAMPT (0.61) | SPRNAMPTHSD11B1PROKR1ROCK2 | |
| SCHEMBL2388346 | 0.81 | NAMPT (0.58) | SPRNAMPTHSD11B1PROKR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | claimed |