Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.80 |
| ▸ | INSR | P06213 | 8/20 | 0.80 |
| ▸ | JAK2 | O60674 | 10/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | NPM1 | P06748 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521179 | 0.90 | ALK (0.75) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL520258 | 0.89 | ALK (0.78) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL3467110 | 0.89 | INSR (0.79) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL519479 | 0.89 | ALK (1.00) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL520453 | 0.88 | ALK (0.75) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL3467119 | 0.87 | ALK (0.72) | ALKINSRJAK2CYP3A4JAK3 | |
| SCHEMBL520762 | 0.87 | ALK (0.74) | ALKINSRJAK2CYP3A4JAK3 | |
| SCHEMBL519908 | 0.86 | JAK2 (0.80) | ALKINSRJAK2CYP3A4JAK3 | |
| SCHEMBL522405 | 0.86 | ALK (0.76) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL519994 | 0.86 | ALK (0.83) | ALKINSRJAK2CYP3A4NPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | claimed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |