Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.72 |
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636307 | 0.90 | CYP3A4 (0.62) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL1036031 | 0.87 | CYP3A4 (0.59) | CYP3A4ACHEHPGDGLO1POLB | |
| Methyl Orsellinate SCHEMBL370816 | 0.84 | CYP3A4 (1.00) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL23752499 | 0.81 | GLO1 (1.00) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL12552740 | 0.81 | CYP3A4 (0.74) | CYP3A4ACHEHPGDGLO1CA12 | |
| SCHEMBL8329910 | 0.81 | POLB (0.63) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL950536 | 0.81 | CYP3A4 (1.00) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL20561796 | 0.81 | CYP3A4 (0.68) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL28196195 | 0.80 | GLO1 (0.70) | CYP3A4ACHEHPGDGLO1POLB | |
| SCHEMBL12554705 | 0.80 | CYP3A4 (0.52) | CYP3A4ACHEHPGDGLO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8329742-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| EP-2231515-B1 | PROCESS FOR PRODUCING CARBON | SUMITOMO CHEMICAL CO (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-20100316555-A1 | PROCESS FOR PRODUCING CARBON | Sumitomt Chemical Company, Limited (JP) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | CYP3A4 1204/4885ACHE 4488/4885HPGD 779/4885 |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT4, VEGFA, FLT1 | CYP3A4 1158/4885ACHE 4033/4885HPGD 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.