Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339826 | 0.89 | PDE4D (0.54) | PDE4APDE4DJAK2 | |
| SCHEMBL15071067 | 0.88 | PDE4D (0.52) | PDE4APDE4D | |
| SCHEMBL508584 | 0.83 | PDE4D (0.55) | PDE4APDE4D | |
| SCHEMBL3469402 | 0.79 | PDE4A (0.58) | PDE4APDE4D | |
| SCHEMBL509408 | 0.78 | JAK2 (0.45) | PDE4APDE4DJAK2 | |
| SCHEMBL509404 | 0.77 | PDE4D (0.53) | PDE4APDE4DJAK2 | |
| SCHEMBL16339827 | 0.76 | JAK2 (0.40) | JAK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7040079 | 0.76 | JAK2 (0.48) | JAK2ROCK2 | |
| SCHEMBL509295 | 0.74 | PDE4D (0.43) | PDE4APDE4D | |
| SCHEMBL29610763 | 0.73 | JAK2 (0.38) | PDE4AJAK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379548-B1 | TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES | LEO PHARMA AS (DK) | 2016-03-09 | — | — | EP | disclosed |
| US-8952162-B2 | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases | LEO PHARMA A/S (DK) | 2015-02-10 | — | — | US | disclosed |
| WO-2010069322-A1 | TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES | LEO PHARMA A/S (DK) | 2010-06-24 | — | — | WO | disclosed |