SCHEMBL3469724

SCHEMBL3469724

COc1ccc(Nc2nccn3c(-c4cccc(C(=O)NCCO)c4)cnc23)cc1

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FYN P06241 10/20 0.51
RAD52 P43351 4/20 0.50
TTK P33981 2/20 0.48
ABL1 P00519 2/20 0.46
BCR P11274 2/20 0.46
AURKA O14965 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3469526 0.88 TTK (0.48) FYNTTK
SCHEMBL3469315 0.86 SYK (0.51) FYNTTKAURKA
SCHEMBL3466032 0.82 RAD52 (0.49) FYNRAD52TTKABL1BCR
SCHEMBL22123392 0.82 TTK (0.51) FYNTTK
SCHEMBL30171705 0.82 TTK (0.51) FYNTTK
SCHEMBL3466981 0.78 SRC (0.56) FYNTTKAURKA
SCHEMBL22124774 0.78 TTK (0.53) TTK
SCHEMBL3477971 0.78 TTK (0.64) FYNTTK
SCHEMBL22124678 0.78 TTK (0.46) TTKABL1BCR
Hydrochloric Acid SCHEMBL30171549 0.78 TTK (0.52) TTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010069684-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-06-24 WO claimed
WO-2010069684-A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY BIOMARIN IGA, LTD. (BS) 2010-06-24 WO disclosed