Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.59 |
| ▸ | CLK1 | P49759 | 3/20 | 0.50 |
| ▸ | CLK2 | P49760 | 3/20 | 0.50 |
| ▸ | CLK3 | P49761 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469485 | 0.84 | TTK (0.57) | TTKCLK1USP2MAPTKMT2A | |
| SCHEMBL3469850 | 0.84 | CLK4 (0.51) | TTKCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL3471979 | 0.83 | TTK (0.61) | TTKUSP2MAPTKMT2A | |
| SCHEMBL5408543 | 0.82 | FLT3 (0.49) | TTKCLK4USP2MAPTKMT2A | |
| SCHEMBL3469399 | 0.80 | TTK (0.72) | TTKADORA3 | |
| SCHEMBL3470503 | 0.80 | MAPK8 (0.44) | TTKADORA3MAPT | |
| SCHEMBL3469537 | 0.79 | FYN (0.51) | TTKCLK1CLK2CLK3DYRK1A | |
| SCHEMBL3469144 | 0.79 | TTK (0.61) | TTKADORA3 | |
| SCHEMBL12409236 | 0.77 | ALDH1A1 (0.47) | TTKCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL3471655 | 0.77 | FYN (0.59) | TTKCLK4MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |