Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 7/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472319 | 0.90 | RXRA (0.57) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3474002 | 0.88 | KMT2A (0.53) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL27738021 | 0.87 | KCNH2 (0.45) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3470718 | 0.85 | RXRA (0.56) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3473869 | 0.83 | NR1H2 (0.45) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3473773 | 0.78 | NR1H2 (0.61) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3475403 | 0.73 | NR1H2 (0.58) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3475558 | 0.72 | RXRA (0.66) | KMT2AMEN1RXRANR1H2NR1H3 | |
| SCHEMBL3472055 | 0.71 | NR1H2 (0.81) | RXRANR1H2NR1H3KCNH2CHRNA7 | |
| SCHEMBL3472145 | 0.71 | NR1H2 (0.67) | RXRANR1H2NR1H3KCNH2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | KMT2A 2663/4885MEN1 3666/4885RXRA 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.