Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472099 | 0.91 | RXRA (0.48) | RXRANR1H2NR1H3NR3C2HTT | |
| SCHEMBL3472681 | 0.89 | RXRA (0.45) | RXRANR1H2NR1H3NR3C2HTT | |
| SCHEMBL3472663 | 0.85 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3474009 | 0.85 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2PTGER1 | |
| SCHEMBL3475415 | 0.84 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2ALDH1A1 | |
| SCHEMBL3472781 | 0.84 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2HTT | |
| SCHEMBL3471783 | 0.83 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3474016 | 0.83 | RXRA (0.50) | RXRANR1H2NR1H3NR3C2NPSR1 | |
| SCHEMBL3473200 | 0.83 | RXRA (0.52) | RXRANR1H2NR1H3NR3C2HPGD | |
| SCHEMBL3472482 | 0.82 | NR1H2 (0.45) | RXRANR1H2NR1H3NR3C2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.