Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472132 | 0.88 | RXRA (0.42) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL15690841 | 0.80 | SYK (0.42) | RXRANR1H2NR1H3HTTTRPV1 | |
| SCHEMBL3473693 | 0.77 | RXRA (0.43) | PTGS2RXRANR1H2NR1H3KDM4E | |
| SCHEMBL3473415 | 0.75 | NR1H2 (0.64) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL3472736 | 0.72 | RXRA (0.45) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL3472412 | 0.72 | RXRA (0.37) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL3471814 | 0.71 | MAPT (0.39) | PTGS2RXRANR1H2NR1H3KDM4E | |
| SCHEMBL3471620 | 0.69 | RXRA (0.66) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL3471768 | 0.68 | RXRA (0.65) | CYP2C9PTGS2RXRANR1H2NR1H3 | |
| SCHEMBL3474792 | 0.68 | RXRA (0.59) | PTGS2RXRANR1H2NR1H3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | claimed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | CYP2C9 141/4885PTGS2 1500/4885RXRA 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.